The break is over, and Casualty returns with an explosive new chapter in the gripping boxset Supply and Demand. Holby City’s ED is about to be rocked by a dangerous cocktail of secrets, suspicions, and unexpected twists. This isn’t just another episode—it’s a storm brewing behind nightclub doors and emergency ward curtains.

1. Indie’s Goodbye Turns Into Something Much Darker

Indie has always been the steady force in the middle of the chaos, but when she covers for Teddy during a near-fatal callout, she finds herself at the crossroads of loyalty and ambition. Jan, stern as ever, makes it clear that there’s no future for Indie in Holby. That’s when the opportunity from Sheffield lands on her lap—a lifeline she can’t ignore.

What should have been a bittersweet farewell quickly becomes messy. During the celebratory night out, Indie extends a subtle invitation to Cam. But in a crushing moment of miscommunication, he doesn’t see it as a date—and turns her down cold.

2. Faith Smells Something Rotten in the Morphine

Iain may be in the clear after his brush with Marburg, but Faith senses something isn’t right—especially with Teddy. When two drug-related patient complaints arise—one begging for more pain relief and another claiming the morphine didn’t work—Faith begins connecting dots.

Could one of their own be tampering with meds? Her instincts scream that something sinister is going on. The question is: will she uncover it before someone dies?

3. Nightclub Highs Become Life-or-Death Lows

Indie’s night out spirals into chaos. At the club, she reconnects with an old friend, Badger, who’s packing more than just memories—he’s carrying a stash of party pills. Teddy and Jodie dive in headfirst, swept up in the moment.

But back in the ED, Siobhan receives a chilling alert: there’s a lethal batch of party drugs circulating. Panic sets in as the reality hits—some of their own may have taken them. Flynn, Siobhan, Stevie, Ngozi, and Nicole brace themselves for a nightmare as the resus room becomes ground zero for drug-related emergencies. Will all of Holby’s team make it out alive?

4. Cassie Returns—and Brings Danger With Her

Nicole isn’t thrilled to see Cassie back in the ED. This time, Cassie’s not the patient—she’s escorting a friend, Steph, who’s overdosed. Worse still, Cassie’s revealed to be one of the drug dealers.

But beneath the hardened exterior is a desperate girl caught in a trap. Nicole probes Steph about their situation and learns the terrifying extent of the abuse both girls have endured. Will Nicole look past her anger to save Cassie from a life she never chose?

5. Rash Fumbles the Bag (and the Romance)

Rash has a plan—a sweet date with Sunny. But in typical Rash fashion, he messes up the tickets and the plans collapse. Rida pokes fun but tries to help, suggesting he bring Sunny to the club instead.

It backfires spectacularly. Sunny, already uncomfortable with the chaos, is furious at the last-minute change. Rash’s chance at love might already be dead in the water. Can he redeem himself—or has his heart misfired once again?

As tensions mount, lives hang in the balance and relationships buckle under pressure. Casualty is back with a vengeance, and this time, no one is safe.

Will Indie leave Holby for good? Can Faith expose the morphine saboteur? And who won’t survive the club night from hell?